2022 Mercedes-Benz Cls450 4matic vs Acura Tlx — Side by Side Comparison

How does the 2022 Mercedes-Benz Cls450 4matic compare to the Acura Tlx? We put them side by side using EPA fuel economy data and NHTSA safety ratings.

Specifications Comparison

FeatureMercedes-Benz Cls450 4maticAcura Tlx
Combined MPG2525
City MPG2222
Highway MPG3031
Body StyleCompact SedanCompact Sedan
Drive4WDFWD
Fuel TypePremiumPremium
Safety RatingN/A / 5N/A / 5
Recalls00
Trims Available12

Fuel Economy

The Acura Tlx is more fuel efficient by 0 MPG combined. Over a year, the Acura Tlx saves approximately $0 in fuel costs.

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