2025 Mercedes-Benz Amg C63 S E Performance vs Lexus IS 500 — Side by Side Comparison

How does the 2025 Mercedes-Benz Amg C63 S E Performance compare to the Lexus IS 500? We put them side by side using EPA fuel economy data and NHTSA safety ratings.

Specifications Comparison

FeatureMercedes-Benz Amg C63 S E PerformanceLexus IS 500
Combined MPG2020
City MPG1917
Highway MPG2225
Body StyleCompact SedanCompact Sedan
DriveAWDRWD
Fuel TypePHEVPremium
Safety RatingN/A / 5N/A / 5
Recalls00
Trims Available11

Fuel Economy

The Lexus IS 500 is more fuel efficient by 0 MPG combined. Over a year, the Lexus IS 500 saves approximately $0 in fuel costs.

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