2022 Lexus RX 350 L vs Acura Mdx — Side by Side Comparison

How does the 2022 Lexus RX 350 L compare to the Acura Mdx? We put them side by side using EPA fuel economy data and NHTSA safety ratings.

Specifications Comparison

FeatureLexus RX 350 LAcura Mdx
Combined MPG2222
City MPG1919
Highway MPG2626
Body StyleCompact SUVCompact SUV
DriveFWDAWD
Fuel TypeRegularPremium
Safety RatingN/A / 5N/A / 5
Recalls00
Trims Available22

Fuel Economy

The Acura Mdx is more fuel efficient by 0 MPG combined. Over a year, the Lexus RX 350 L saves approximately $800 in fuel costs.

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