2025 Audi S5 vs Lexus LS 500 — Side by Side Comparison

How does the 2025 Audi S5 compare to the Lexus LS 500? We put them side by side using EPA fuel economy data and NHTSA safety ratings.

Specifications Comparison

FeatureAudi S5Lexus LS 500
Combined MPG2222
City MPG1918
Highway MPG2829
Body StyleSedanSedan
DriveAWDRWD
Fuel TypePremiumPremium
Safety RatingN/A / 5N/A / 5
Recalls00
Trims Available12

Fuel Economy

The Lexus LS 500 is more fuel efficient by 0 MPG combined. Over a year, the Lexus LS 500 saves approximately $0 in fuel costs.

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