2006 Audi S4 Avant vs Mercedes-Benz E350 4matic (Wagon) — Side by Side Comparison

How does the 2006 Audi S4 Avant compare to the Mercedes-Benz E350 4matic (Wagon)? We put them side by side using EPA fuel economy data and NHTSA safety ratings.

Specifications Comparison

FeatureAudi S4 AvantMercedes-Benz E350 4matic (Wagon)
Combined MPG1618
City MPG1416
Highway MPG2122
Body StyleWagonWagon
DriveAWD/4WDAWD/4WD
Fuel TypePremiumPremium
Safety RatingN/A / 5N/A / 5
Recalls00
Trims Available21

Fuel Economy

The Mercedes-Benz E350 4matic (Wagon) is more fuel efficient by 2 MPG combined. Over a year, the Mercedes-Benz E350 4matic (Wagon) saves approximately $400 in fuel costs.

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