2025 Mercedes-Benz S580e 4matic

Full-Size Sedan PHEV Plug-in Hybrid
Mercedes-Benz S580e 4matic 2025
23MPG Combined
1 Trim
← 2023 2025
Updated February 27, 2026

The 2025 Mercedes-Benz S580e 4matic Full-Size Sedan provides 23 combined MPG. We’ve compiled EPA fuel economy data, NHTSA safety ratings, and recall history so you can make an informed decision.

2025 Mercedes-Benz S580e 4matic Specifications

SpecValue
Combined MPG23 combined MPG
City MPG20
Highway MPG29
Body StyleFull-Size Sedan
Fuel TypePHEV
DriveAWD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2025 Mercedes-Benz S580e 4matic costs approximately $2,550 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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