2022 Mercedes-Benz S580 4matic

Full-Size Sedan Premium
Mercedes-Benz S580 4matic 2022
19MPG Combined
1 Trim
← 2021 2022 2023 →
Updated February 27, 2026

Get the full picture on the 2022 Mercedes-Benz S580 4matic. As a Full-Size Sedan, it achieves 19 combined MPG and has not yet been rated by NHTSA. Below you’ll find detailed specs for every trim, plus recall information and competitor comparisons.

2022 Mercedes-Benz S580 4matic Specifications

SpecValue
Combined MPG19 combined MPG
City MPG16
Highway MPG25
Body StyleFull-Size Sedan
Fuel TypePremium
DriveAWD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2022 Mercedes-Benz S580 4matic costs approximately $3,050 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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