2021 Mercedes-Benz S580 4matic

Full-Size Sedan Premium
Mercedes-Benz S580 4matic 2021
20MPG Combined
1 Trim
2021 2022 →
Updated February 27, 2026

The 2021 Mercedes-Benz S580 4matic is a Full-Size Sedan that delivers 20 combined MPG. Here’s everything you need to know about this vehicle, from fuel economy to safety ratings.

2021 Mercedes-Benz S580 4matic Specifications

SpecValue
Combined MPG20 combined MPG
City MPG17
Highway MPG25
Body StyleFull-Size Sedan
Fuel TypePremium
Drive4WD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2021 Mercedes-Benz S580 4matic costs approximately $2,900 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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