2006 Mercedes-Benz S500

Full-Size Sedan Premium
Mercedes-Benz S500 2006
17MPG Combined
1 Trim
← 2005 2006
Updated February 27, 2026

The 2006 Mercedes-Benz S500 is a Full-Size Sedan that delivers 17 combined MPG. Here’s everything you need to know about this vehicle, from fuel economy to safety ratings.

2006 Mercedes-Benz S500 Specifications

SpecValue
Combined MPG17 combined MPG
City MPG14
Highway MPG22
Body StyleFull-Size Sedan
Fuel TypePremium
DriveRWD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2006 Mercedes-Benz S500 costs approximately $3,450 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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