2025 Mercedes-Benz S500 4matic

Full-Size Sedan Premium
Mercedes-Benz S500 4matic 2025
24MPG Combined
1 Trim
← 2024 2025 2026 →
Updated February 27, 2026

Get the full picture on the 2025 Mercedes-Benz S500 4matic. As a Full-Size Sedan, it achieves 24 combined MPG and has not yet been rated by NHTSA. Below you’ll find detailed specs for every trim, plus recall information and competitor comparisons.

2025 Mercedes-Benz S500 4matic Specifications

SpecValue
Combined MPG24 combined MPG
City MPG21
Highway MPG31
Body StyleFull-Size Sedan
Fuel TypePremium
DriveAWD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2025 Mercedes-Benz S500 4matic costs approximately $2,450 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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