2006 Mercedes-Benz S500 4matic

Full-Size Sedan Premium
Mercedes-Benz S500 4matic 2006
16MPG Combined
1 Trim
← 2005 2006 2021 →
Updated February 27, 2026

Looking at the 2006 Mercedes-Benz S500 4matic? This Full-Size Sedan offers 16 combined MPG and comes with 1 available configurations. We break down the specs, safety data, and how it compares to the competition.

2006 Mercedes-Benz S500 4matic Specifications

SpecValue
Combined MPG16 combined MPG
City MPG14
Highway MPG20
Body StyleFull-Size Sedan
Fuel TypePremium
DriveAWD/4WD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2006 Mercedes-Benz S500 4matic costs approximately $3,650 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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