2018 Mercedes-Benz S450 4matic
22MPG
Combined
1
Trim
2018
2019 →
Updated February 27, 2026
Get the full picture on the 2018 Mercedes-Benz S450 4matic. As a Full-Size Sedan, it achieves 22 combined MPG and has not yet been rated by NHTSA. Below you’ll find detailed specs for every trim, plus recall information and competitor comparisons.
2018 Mercedes-Benz S450 4matic Specifications
| Spec | Value |
|---|---|
| Combined MPG | 22 combined MPG |
| City MPG | 18 |
| Highway MPG | 28 |
| Body Style | Full-Size Sedan |
| Fuel Type | Premium |
| Drive | 4WD |
| Available Trims | 1 |
Annual Fuel Cost
Based on EPA estimates, the 2018 Mercedes-Benz S450 4matic costs approximately $2,650 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.
Compare the 2018 Mercedes-Benz S450 4matic
See how it stacks up against similar vehicles:
Other Model Years
- 2020 Mercedes-Benz S450 4matic
- 2019 Mercedes-Benz S450 4matic
- 2018 (this page)
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Considering a used Mercedes-Benz S450 4matic? Get a comprehensive vehicle history report including accident records, ownership history, and more.
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