2010 Mercedes-Benz S400 Hybrid
21MPG
Combined
1
Trim
2010
2011 →
Updated February 27, 2026
Get the full picture on the 2010 Mercedes-Benz S400 Hybrid. As a Full-Size Sedan, it achieves 21 combined MPG and has not yet been rated by NHTSA. Below you’ll find detailed specs for every trim, plus recall information and competitor comparisons.
2010 Mercedes-Benz S400 Hybrid Specifications
| Spec | Value |
|---|---|
| Combined MPG | 21 combined MPG |
| City MPG | 19 |
| Highway MPG | 25 |
| Body Style | Full-Size Sedan |
| Fuel Type | Premium |
| Drive | RWD |
| Available Trims | 1 |
Annual Fuel Cost
Based on EPA estimates, the 2010 Mercedes-Benz S400 Hybrid costs approximately $2,800 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.
Compare the 2010 Mercedes-Benz S400 Hybrid
See how it stacks up against similar vehicles:
Other Model Years
- 2013 Mercedes-Benz S400 Hybrid
- 2012 Mercedes-Benz S400 Hybrid
- 2011 Mercedes-Benz S400 Hybrid
- 2010 (this page)
Check Vehicle History
Considering a used Mercedes-Benz S400 Hybrid? Get a comprehensive vehicle history report including accident records, ownership history, and more.
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