2006 Mercedes-Benz S350

Full-Size Sedan Premium
Mercedes-Benz S350 2006
18MPG Combined
1 Trim
2006
Updated February 27, 2026

Looking at the 2006 Mercedes-Benz S350? This Full-Size Sedan offers 18 combined MPG and comes with 1 available configurations. We break down the specs, safety data, and how it compares to the competition.

2006 Mercedes-Benz S350 Specifications

SpecValue
Combined MPG18 combined MPG
City MPG16
Highway MPG23
Body StyleFull-Size Sedan
Fuel TypePremium
DriveRWD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2006 Mercedes-Benz S350 costs approximately $3,250 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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  • 2006 (this page)

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