2006 Mercedes-Benz E500 4matic
16MPG
Combined
1
Trim
← 2005
2006
Updated February 27, 2026
The 2006 Mercedes-Benz E500 4matic is a Sedan that delivers 16 combined MPG. Here’s everything you need to know about this vehicle, from fuel economy to safety ratings.
2006 Mercedes-Benz E500 4matic Specifications
| Spec | Value |
|---|---|
| Combined MPG | 16 combined MPG |
| City MPG | 14 |
| Highway MPG | 19 |
| Body Style | Sedan |
| Fuel Type | Premium |
| Drive | AWD/4WD |
| Available Trims | 1 |
Annual Fuel Cost
Based on EPA estimates, the 2006 Mercedes-Benz E500 4matic costs approximately $3,650 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.
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Other Model Years
- 2006 (this page)
- 2005 Mercedes-Benz E500 4matic
- 2004 Mercedes-Benz E500 4matic
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