2022 Mercedes-Benz E450 4matic

Sedan Premium
Mercedes-Benz E450 4matic 2022
25MPG Combined
1 Trim
← 2021 2022 2023 →
Updated February 27, 2026

The 2022 Mercedes-Benz E450 4matic is a Sedan that delivers 25 combined MPG. Here’s everything you need to know about this vehicle, from fuel economy to safety ratings.

2022 Mercedes-Benz E450 4matic Specifications

SpecValue
Combined MPG25 combined MPG
City MPG23
Highway MPG30
Body StyleSedan
Fuel TypePremium
Drive4WD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2022 Mercedes-Benz E450 4matic costs approximately $2,350 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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