2022 Mercedes-Benz E450 4matic All-Terrain (Wagon)

Wagon Premium
Mercedes-Benz E450 4matic All-Terrain (Wagon) 2022
24MPG Combined
1 Trim
← 2021 2022 2023 →
Updated February 27, 2026

The 2022 Mercedes-Benz E450 4matic All-Terrain (Wagon) is a Wagon that delivers 24 combined MPG. Here’s everything you need to know about this vehicle, from fuel economy to safety ratings.

2022 Mercedes-Benz E450 4matic All-Terrain (Wagon) Specifications

SpecValue
Combined MPG24 combined MPG
City MPG21
Highway MPG28
Body StyleWagon
Fuel TypePremium
Drive4WD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2022 Mercedes-Benz E450 4matic All-Terrain (Wagon) costs approximately $2,450 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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