2021 Mercedes-Benz E450 4matic All-Terrain (Wagon)

Wagon Premium
Mercedes-Benz E450 4matic All-Terrain (Wagon) 2021
24MPG Combined
1 Trim
2021 2022 →
Updated February 27, 2026

Get the full picture on the 2021 Mercedes-Benz E450 4matic All-Terrain (Wagon). As a Wagon, it achieves 24 combined MPG and has not yet been rated by NHTSA. Below you’ll find detailed specs for every trim, plus recall information and competitor comparisons.

2021 Mercedes-Benz E450 4matic All-Terrain (Wagon) Specifications

SpecValue
Combined MPG24 combined MPG
City MPG22
Highway MPG28
Body StyleWagon
Fuel TypePremium
Drive4WD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2021 Mercedes-Benz E450 4matic All-Terrain (Wagon) costs approximately $2,450 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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