2016 Mercedes-Benz E400 4matic

Sedan Premium
Mercedes-Benz E400 4matic 2016
22MPG Combined
1 Trim
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Updated February 27, 2026

Get the full picture on the 2016 Mercedes-Benz E400 4matic. As a Sedan, it achieves 22 combined MPG and has not yet been rated by NHTSA. Below you’ll find detailed specs for every trim, plus recall information and competitor comparisons.

2016 Mercedes-Benz E400 4matic Specifications

SpecValue
Combined MPG22 combined MPG
City MPG20
Highway MPG27
Body StyleSedan
Fuel TypePremium
Drive4WD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2016 Mercedes-Benz E400 4matic costs approximately $2,650 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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