2021 Mercedes-Benz E350

Sedan Premium
Mercedes-Benz E350 2021
25MPG Combined
1 Trim
← 2020 2021 2022 →
Updated February 27, 2026

The 2021 Mercedes-Benz E350 Sedan provides 25 combined MPG. We’ve compiled EPA fuel economy data, NHTSA safety ratings, and recall history so you can make an informed decision.

2021 Mercedes-Benz E350 Specifications

SpecValue
Combined MPG25 combined MPG
City MPG22
Highway MPG31
Body StyleSedan
Fuel TypePremium
DriveRWD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2021 Mercedes-Benz E350 costs approximately $2,350 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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