2016 Mercedes-Benz E350

Sedan Premium or E85
Mercedes-Benz E350 2016
23MPG Combined
2 Trims
← 2015 2016 2020 →
Updated February 27, 2026

The 2016 Mercedes-Benz E350 Sedan provides 23 combined MPG. We’ve compiled EPA fuel economy data, NHTSA safety ratings, and recall history so you can make an informed decision.

2016 Mercedes-Benz E350 Specifications

SpecValue
Combined MPG23 combined MPG
City MPG20
Highway MPG28
Body StyleSedan
Fuel TypePremium or E85
DriveRWD
Available Trims2

Available Trims

TrimMPG (City/Hwy/Combined)EngineTransmission
Auto20/28/233.5L 6cylAutomatic 7-spd
Auto20/28/233.5L 6cylAutomatic 7-spd

Annual Fuel Cost

Based on EPA estimates, the 2016 Mercedes-Benz E350 costs approximately $2,550 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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