2016 Mercedes-Benz E350 4matic (Wagon)

Wagon Premium
Mercedes-Benz E350 4matic (Wagon) 2016
22MPG Combined
1 Trim
← 2015 2016
Updated February 27, 2026

Get the full picture on the 2016 Mercedes-Benz E350 4matic (Wagon). As a Wagon, it achieves 22 combined MPG and has not yet been rated by NHTSA. Below you’ll find detailed specs for every trim, plus recall information and competitor comparisons.

2016 Mercedes-Benz E350 4matic (Wagon) Specifications

SpecValue
Combined MPG22 combined MPG
City MPG20
Highway MPG26
Body StyleWagon
Fuel TypePremium
Drive4WD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2016 Mercedes-Benz E350 4matic (Wagon) costs approximately $2,650 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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