2006 Mercedes-Benz C280

Compact Sedan Premium
Mercedes-Benz C280 2006
21MPG Combined
1 Trim
← 2000 2006 2007 →
Updated February 27, 2026

The 2006 Mercedes-Benz C280 Compact Sedan provides 21 combined MPG. We’ve compiled EPA fuel economy data, NHTSA safety ratings, and recall history so you can make an informed decision.

2006 Mercedes-Benz C280 Specifications

SpecValue
Combined MPG21 combined MPG
City MPG18
Highway MPG26
Body StyleCompact Sedan
Fuel TypePremium
DriveRWD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2006 Mercedes-Benz C280 costs approximately $2,800 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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