2022 Mercedes-Benz Amg E53 4matic Plus

Sedan Premium
Mercedes-Benz Amg E53 4matic Plus 2022
24MPG Combined
1 Trim
← 2021 2022 2023 →
Updated February 27, 2026

Looking at the 2022 Mercedes-Benz Amg E53 4matic Plus? This Sedan offers 24 combined MPG and comes with 1 available configurations. We break down the specs, safety data, and how it compares to the competition.

2022 Mercedes-Benz Amg E53 4matic Plus Specifications

SpecValue
Combined MPG24 combined MPG
City MPG21
Highway MPG29
Body StyleSedan
Fuel TypePremium
Drive4WD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2022 Mercedes-Benz Amg E53 4matic Plus costs approximately $2,450 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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