2025 Lexus RX 350

Compact SUV Premium
Lexus RX 350 2025
25MPG Combined
2 Trims
← 2024 2025 2026 →
Updated February 27, 2026

The 2025 Lexus RX 350 Compact SUV provides 24–25 combined MPG depending on trim. We’ve compiled EPA fuel economy data, NHTSA safety ratings, and recall history so you can make an informed decision.

2025 Lexus RX 350 Specifications

SpecValue
Combined MPG24–25 combined MPG depending on trim
City MPG22
Highway MPG29
Body StyleCompact SUV
Fuel TypePremium
DriveFWD
Available Trims2

Available Trims

TrimMPG (City/Hwy/Combined)EngineTransmission
4 cyl22/29/252.4L 4cylAutomatic (S8)
4 cyl21/28/242.4L 4cylAutomatic (S8)

Annual Fuel Cost

Based on EPA estimates, the 2025 Lexus RX 350 costs approximately $2,400 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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