2022 Lexus RX 350

Compact SUV Regular
Lexus RX 350 2022
23MPG Combined
2 Trims
← 2021 2022 2023 →
Updated February 27, 2026

Looking at the 2022 Lexus RX 350? This Compact SUV offers 22–23 combined MPG depending on trim and comes with 2 available configurations. We break down the specs, safety data, and how it compares to the competition.

2022 Lexus RX 350 Specifications

SpecValue
Combined MPG22–23 combined MPG depending on trim
City MPG20
Highway MPG27
Body StyleCompact SUV
Fuel TypeRegular
DriveFWD
Available Trims2

Available Trims

TrimMPG (City/Hwy/Combined)EngineTransmission
6 cyl20/27/233.5L 6cylAutomatic (S8)
6 cyl19/26/223.5L 6cylAutomatic (S8)

Annual Fuel Cost

Based on EPA estimates, the 2022 Lexus RX 350 costs approximately $1,950 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

Compare the 2022 Lexus RX 350

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