2021 Lexus RX 350

Compact SUV Regular
Lexus RX 350 2021
23MPG Combined
2 Trims
← 2020 2021 2022 →
Updated February 27, 2026

Get the full picture on the 2021 Lexus RX 350. As a Compact SUV, it achieves 22–23 combined MPG depending on trim and has not yet been rated by NHTSA. Below you’ll find detailed specs for every trim, plus recall information and competitor comparisons.

2021 Lexus RX 350 Specifications

SpecValue
Combined MPG22–23 combined MPG depending on trim
City MPG20
Highway MPG27
Body StyleCompact SUV
Fuel TypeRegular
DriveFWD
Available Trims2

Available Trims

TrimMPG (City/Hwy/Combined)EngineTransmission
6 cyl20/27/233.5L 6cylAutomatic (S8)
6 cyl19/26/223.5L 6cylAutomatic (S8)

Annual Fuel Cost

Based on EPA estimates, the 2021 Lexus RX 350 costs approximately $1,950 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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