2012 Lexus RX 350

SUV Regular
Lexus RX 350 2012
21MPG Combined
2 Trims
← 2011 2012 2013 →
Updated February 27, 2026

The 2012 Lexus RX 350 SUV provides 20–21 combined MPG depending on trim. We’ve compiled EPA fuel economy data, NHTSA safety ratings, and recall history so you can make an informed decision.

2012 Lexus RX 350 Specifications

SpecValue
Combined MPG20–21 combined MPG depending on trim
City MPG18
Highway MPG25
Body StyleSUV
Fuel TypeRegular
DriveFWD
Available Trims2

Available Trims

TrimMPG (City/Hwy/Combined)EngineTransmission
6 cyl18/25/213.5L 6cylAutomatic (S6)
6 cyl18/24/203.5L 6cylAutomatic (S6)

Annual Fuel Cost

Based on EPA estimates, the 2012 Lexus RX 350 costs approximately $2,150 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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