2010 Lexus RX 350

SUV Premium
Lexus RX 350 2010
21MPG Combined
2 Trims
← 2009 2010 2011 →
Updated February 27, 2026

The 2010 Lexus RX 350 SUV provides 20–21 combined MPG depending on trim. We’ve compiled EPA fuel economy data, NHTSA safety ratings, and recall history so you can make an informed decision.

2010 Lexus RX 350 Specifications

SpecValue
Combined MPG20–21 combined MPG depending on trim
City MPG18
Highway MPG25
Body StyleSUV
Fuel TypePremium
DriveAWD
Available Trims2

Available Trims

TrimMPG (City/Hwy/Combined)EngineTransmission
6 cyl18/24/203.5L 6cylAutomatic (S6)
6 cyl18/25/213.5L 6cylAutomatic (S6)

Annual Fuel Cost

Based on EPA estimates, the 2010 Lexus RX 350 costs approximately $2,850 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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