2021 Lexus RX 350 L
22MPG
Combined
2
Trims
Updated February 27, 2026
The 2021 Lexus RX 350 L Compact SUV provides 21–22 combined MPG depending on trim. We’ve compiled EPA fuel economy data, NHTSA safety ratings, and recall history so you can make an informed decision.
2021 Lexus RX 350 L Specifications
| Spec | Value |
|---|---|
| Combined MPG | 21–22 combined MPG depending on trim |
| City MPG | 19 |
| Highway MPG | 26 |
| Body Style | Compact SUV |
| Fuel Type | Regular |
| Drive | FWD |
| Available Trims | 2 |
Available Trims
| Trim | MPG (City/Hwy/Combined) | Engine | Transmission |
|---|---|---|---|
| 6 cyl | 19/26/22 | 3.5L 6cyl | Automatic (S8) |
| 6 cyl | 18/25/21 | 3.5L 6cyl | Automatic (S8) |
Annual Fuel Cost
Based on EPA estimates, the 2021 Lexus RX 350 L costs approximately $2,050 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.
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