2021 Lexus LS 500h
28MPG
Combined
2
Trims
Updated February 27, 2026
The 2021 Lexus LS 500h Sedan provides 26–28 combined MPG depending on trim. We’ve compiled EPA fuel economy data, NHTSA safety ratings, and recall history so you can make an informed decision.
2021 Lexus LS 500h Specifications
| Spec | Value |
|---|---|
| Combined MPG | 26–28 combined MPG depending on trim |
| City MPG | 25 |
| Highway MPG | 33 |
| Body Style | Sedan |
| Fuel Type | Premium |
| Drive | AWD |
| Available Trims | 2 |
Available Trims
| Trim | MPG (City/Hwy/Combined) | Engine | Transmission |
|---|---|---|---|
| 6 cyl | 23/29/26 | 3.5L 6cyl | Automatic (AV-S10) |
| 6 cyl | 25/33/28 | 3.5L 6cyl | Automatic (AV-S10) |
Annual Fuel Cost
Based on EPA estimates, the 2021 Lexus LS 500h costs approximately $2,175 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.
Compare the 2021 Lexus LS 500h
See how it stacks up against similar vehicles:
Other Model Years
- 2025 Lexus LS 500h
- 2024 Lexus LS 500h
- 2023 Lexus LS 500h
- 2022 Lexus LS 500h
- 2021 (this page)
- 2020 Lexus LS 500h
- 2019 Lexus LS 500h
- 2018 Lexus LS 500h
Check Vehicle History
Considering a used Lexus LS 500h? Get a comprehensive vehicle history report including accident records, ownership history, and more.
🔍 Check Lexus LS 500h Vehicle History
Check VIN →
Check Vehicle History
Check VINGet the full story — accidents, ownership, recalls, odometer, and more. Decode any VIN instantly.