2021 Lexus LS 500

Sedan Premium
Lexus LS 500 2021
22MPG Combined
2 Trims
← 2020 2021 2022 →
Updated February 27, 2026

The 2021 Lexus LS 500 Sedan provides 21–22 combined MPG depending on trim. We’ve compiled EPA fuel economy data, NHTSA safety ratings, and recall history so you can make an informed decision.

2021 Lexus LS 500 Specifications

SpecValue
Combined MPG21–22 combined MPG depending on trim
City MPG18
Highway MPG29
Body StyleSedan
Fuel TypePremium
DriveRWD
Available Trims2

Available Trims

TrimMPG (City/Hwy/Combined)EngineTransmission
6 cyl18/29/223.4L 6cylAutomatic (S10)
6 cyl17/27/213.4L 6cylAutomatic (S10)

Annual Fuel Cost

Based on EPA estimates, the 2021 Lexus LS 500 costs approximately $2,725 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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