2022 Lexus IS 500

Compact Sedan Premium
Lexus IS 500 2022
20MPG Combined
1 Trim
2022 2023 →
Updated February 27, 2026

The 2022 Lexus IS 500 Compact Sedan provides 20 combined MPG. We’ve compiled EPA fuel economy data, NHTSA safety ratings, and recall history so you can make an informed decision.

2022 Lexus IS 500 Specifications

SpecValue
Combined MPG20 combined MPG
City MPG17
Highway MPG25
Body StyleCompact Sedan
Fuel TypePremium
DriveRWD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2022 Lexus IS 500 costs approximately $2,900 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

Compare the 2022 Lexus IS 500

See how it stacks up against similar vehicles:

Other Model Years

Check Vehicle History

Considering a used Lexus IS 500? Get a comprehensive vehicle history report including accident records, ownership history, and more.

🔍 Check Lexus IS 500 Vehicle History Check VIN →
Check Vehicle History

Get the full story — accidents, ownership, recalls, odometer, and more. Decode any VIN instantly.

Check VIN
Buying a used Lexus IS 500? Check VIN on RedVIN