2021 Lexus IS 350

Compact Sedan Premium
Lexus IS 350 2021
23MPG Combined
2 Trims
← 2020 2021 2022 →
Updated February 27, 2026

The 2021 Lexus IS 350 Compact Sedan provides 22–23 combined MPG depending on trim. We’ve compiled EPA fuel economy data, NHTSA safety ratings, and recall history so you can make an informed decision.

2021 Lexus IS 350 Specifications

SpecValue
Combined MPG22–23 combined MPG depending on trim
City MPG20
Highway MPG28
Body StyleCompact Sedan
Fuel TypePremium
DriveRWD
Available Trims2

Available Trims

TrimMPG (City/Hwy/Combined)EngineTransmission
6 cyl20/28/233.5L 6cylAutomatic (S8)
6 cyl19/26/223.5L 6cylAutomatic (S6)

Annual Fuel Cost

Based on EPA estimates, the 2021 Lexus IS 350 costs approximately $2,600 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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