2016 Lexus IS 350

Compact Sedan Premium
Lexus IS 350 2016
22MPG Combined
2 Trims
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Updated February 27, 2026

Get the full picture on the 2016 Lexus IS 350. As a Compact Sedan, it achieves 21–22 combined MPG depending on trim and has not yet been rated by NHTSA. Below you’ll find detailed specs for every trim, plus recall information and competitor comparisons.

2016 Lexus IS 350 Specifications

SpecValue
Combined MPG21–22 combined MPG depending on trim
City MPG19
Highway MPG28
Body StyleCompact Sedan
Fuel TypePremium
DriveRWD
Available Trims2

Available Trims

TrimMPG (City/Hwy/Combined)EngineTransmission
6 cyl19/28/223.5L 6cylAutomatic (S8)
6 cyl19/26/213.5L 6cylAutomatic (S6)

Annual Fuel Cost

Based on EPA estimates, the 2016 Lexus IS 350 costs approximately $2,725 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

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