2006 Lexus IS 350

Compact Sedan Premium
Lexus IS 350 2006
21MPG Combined
1 Trim
2006 2007 →
Updated February 27, 2026

Looking at the 2006 Lexus IS 350? This Compact Sedan offers 21 combined MPG and comes with 1 available configurations. We break down the specs, safety data, and how it compares to the competition.

2006 Lexus IS 350 Specifications

SpecValue
Combined MPG21 combined MPG
City MPG19
Highway MPG26
Body StyleCompact Sedan
Fuel TypePremium
DriveRWD
Available Trims1

Annual Fuel Cost

Based on EPA estimates, the 2006 Lexus IS 350 costs approximately $2,800 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.

Compare the 2006 Lexus IS 350

See how it stacks up against similar vehicles:

Other Model Years

Check Vehicle History

Considering a used Lexus IS 350? Get a comprehensive vehicle history report including accident records, ownership history, and more.

🔍 Check Lexus IS 350 Vehicle History Check VIN →
Check Vehicle History

Get the full story — accidents, ownership, recalls, odometer, and more. Decode any VIN instantly.

Check VIN
Buying a used Lexus IS 350? Check VIN on RedVIN