2006 Isuzu i-280 Extended Cab
21MPG
Combined
2
Trims
2006
Updated February 27, 2026
Get the full picture on the 2006 Isuzu i-280 Extended Cab. As a Truck, it achieves 17–21 combined MPG depending on trim and has not yet been rated by NHTSA. Below you’ll find detailed specs for every trim, plus recall information and competitor comparisons.
2006 Isuzu i-280 Extended Cab Specifications
| Spec | Value |
|---|---|
| Combined MPG | 17–21 combined MPG depending on trim |
| City MPG | 18 |
| Highway MPG | 25 |
| Body Style | Truck |
| Fuel Type | Regular |
| Drive | RWD |
| Available Trims | 2 |
Available Trims
| Trim | MPG (City/Hwy/Combined) | Engine | Transmission |
|---|---|---|---|
| Auto | 15/22/17 | 2.8L 4cyl | Automatic 4-spd |
| Man | 18/25/21 | 2.8L 4cyl | Manual 5-spd |
Annual Fuel Cost
Based on EPA estimates, the 2006 Isuzu i-280 Extended Cab costs approximately $2,350 per year in fuel. This assumes 15,000 miles driven annually and current fuel prices.
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Other Model Years
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